Impact of inhibitory interneuron plasticity on cortical function and homeostasis

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Owen Mackwood

Inspired by prior theoretical work on GABAergic synaptic plasticity, this project investigates how long-term changes to inhibition can be homeostatic for principal cells. Employing a normative approach, various types of plasticity affecting inhibition, both synaptic and intrinsic are mathematically derived. We then characterise the functional consequences of the derived forms of plasticity in computational models of mammalian sensory cortex.