Presynaptic InhibitionBack to Research
Presynaptic GABA(B) receptors have been shown to modulate the activity of neural circuits by inhibiting calcium channels which causes a reduction in neurotransmitter release. Activation of presynaptic GABA(B) receptors at excitatory synapses occurs as a result of GABA spillover from nearby inhibitory synapses. Therefore presynaptic inhibition is a compensatory process that multiplicatively alters effective synaptic strength. We investigate the functional implications of such a mechanism using simulations of biologically inspired spiking networks and mathematical analyses of simplified phenomenological models.