Preprints

Neural mechanisms of predictive processing: a collaborative community experiment through the OpenScope program Ido Aizenbud, Nicholas Audette, ..., Loreen Hertäg, ..., Yihan Sophy Xiong arxiv, 2025

2026

A population approach to cortical GABAergic interneuron function The IN-CODE consortium Neuron, in press
Memory consolidation and representational drift Denis Alevi, Felix Lundt, Simone Ciceri, Kris Heiney, Henning Sprekeler bioRxiv
Innate development of cognitive functions and motor programs by chemoaffinity Friedrich Schuessler, Simone Ciceri, Henning Sprekeler bioRxiv
Information theoretic measures of neural and behavioural coupling predict representational drift Kristine Heiney, Mónika Józsa, Michael E. Rule, Henning Sprekeler, Stefano Nichele, Timothy O’Leary PLOS Computational Biology 22 (2), e1013130

2025

Mechanical problem solving in mice Marcus N Boon*, Niek Andresen*, Soledad Traverso*, Sophia Meier, Friedrich Schuessler, Olaf Hellwich, Lars Lewejohann, Christa Thöne-Reineke, Henning Sprekeler+, Katharina Hohlbaum+ bioRxiv
Mouse Lockbox Dataset: Behavior Recognition for Mice Solving Lockboxes Patrik Reiske, Marcus N Boon, Niek Andresen, Sole Traverso, Katharina Hohlbaum, Lars Lewejohann, Christa Thöne-Reineke, Olaf Hellwich, Henning Sprekeler arXiv
Linking homeostasis to reinforcement learning: internal state control of motivated behavior Naoto Yoshida, Henning Sprekeler, Boris Gutkin Current Opinion in Behavioral Sciences 66, 101611
Network models incorporating chloride dynamics predict optimal strategies for terminating status epilepticus Christopher B. Currin, Richard J. Burman, Tommaso Fedele, Georgia Ramantani, Richard E. Rosch, Henning Sprekeler, Joseph V. Raimondo Neurobiology of Disease 212, 106966
Balancing complexity, performance and plausibility to meta learn plasticity rules in recurrent spiking networks Basile Confavreux, Everton J. Agnes, Friedemann Zenke, Henning Sprekeler, Tim P. Vogels PLOS Computational Biology 21(4):e1012910
Layer-specific control of inhibition by NDNF interneurons Laura B. Naumann, Loreen Hertäg, Henning Sprekeler PNAS 122 (4), e2408966122
Self-supervised predictive learning accounts for cortical layer-specificity Kevin Kermani Nejad, Paul Anastasiades, Loreen Hertäg, Rui Ponte Costa Nature Communications 16 (1), 6178
Uncertainty estimation with prediction-error circuits Loreen Hertäg, Katharina Wilmes, Claudia Clopath Nature Communications 16 (1), 3036

2024

Calcium-permeable AMPA receptors govern PV neuron feature selectivity Ingie Hong, Juhyun Kim, Thomas Hainmueller, Dong Won Kim, Joram Keijser, Richard C. Johnson, Soo Hyun Park, Nathachit Limjunyawong, Zhuonan Yang, David Cheon, Taeyoung Hwang, Amit Agarwal, Thibault Cholvin, Fenna M. Krienen, Steven A. McCarroll, Xinzhong Dong, David A. Leopold, Seth Blackshaw, Henning Sprekeler, Dwight E. Bergles, Marlene Bartos, Solange P. Brown, Richard L. Huganir Nature 635 (8038), 398-405
Transcriptomic correlates of state modulation in GABAergic interneurons: A cross-species analysis Joram Keijser, Loreen Hertäg, Henning Sprekeler Journal of Neuroscience 44(44), e2371232024
Discovering Minimal Reinforcement Learning Environments Jarek Liesen, Chris Lu, Andrei Lupu, Jakob N Foerster, Henning Sprekeler, Robert T. Lange arXiv

2023

Lottery Tickets in Evolutionary Optimization: On Sparse Backpropagation-Free Trainability Robert Tjarko Lange, Henning Sprekeler ICML 2023
Discovering Attention-Based Genetic Algorithms via Meta-Black-Box Optimization Robert Tjarko Lange, Tom Schaul, Yutian Chen, Chris Lu, Tom Zahavy, Valentin Dalibard, Sebastian Flennerhag Proceedings of the 2023 Genetic and Evolutionary Computation Conference (GECCO 2023).
Cortical interneurons: fit for function and fit to function? Evidence from development and evolution Joram Keijser & Henning Sprekeler Frontiers in Neural Circuits 17:1172464
Control of neocortical memory by long-range inhibition in layer 1 Anna Schroeder, Belén Pardi, Joram Keijser, Tamas Dalmay, Erin Schuman, Henning Sprekeler, Johannes Letzkus Neuron 111, p. 1-12
Fish shoals resemble a stochastic excitable system driven by environmental perturbations Luis Gómez-Nava, Robert T. Lange, Pascal P. Klamser, Juliane Lukas, Lenin Arias-Rodriguez, David Bierbach, Jens Krause, Henning Sprekeler & Pawel Romanczuk Nature Physics 19, 663–669
Multispecies collective waving behaviour in fish Juliane Lukas, Jens Krause, Arabella Sophie Träger, Jonas Marc Piotrowski, Pawel Romanczuk, Henning Sprekeler, Lenin Arias-Rodriguez, Stefan Krause, Christopher Schutz & David Bierbach Philosophical Transactions of the Royal Society B 378(1874)
Restoring speech intelligibility for hearing aid users with deep learning Peter Udo Diehl, Yosef Singer, Hannes Zilly, Uwe Schönfeld, Paul Meyer-Rachner, Mark Berry, Henning Sprekeler, Elias Sprengel, Annett Pudszuhn & Veit M Hofmann Scientific Reports 13(1), p. 2719
Discovering Evolution Strategies via Meta-Black-Box Optimization Robert Tjarko Lange, Tom Schaul, Yutian Chen, Tom Zahavy, Valentin Dallibard, Chris Lu, Satinder Singh, Sebastian Flennerhag ICLR 2023

2022

Optimizing interneuron circuits for compartment-specific feedback inhibition Joram Keijser, Henning Sprekeler PLOS Computational Biology 18(4), e1009933
Invariant neural subspaces maintained by feedback modulation Laura B. Naumann, Joram Keijser, Henning Sprekeler eLife 11, e7609
Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications Loreen Hertäg, Claudia Clopath PNAS 119 (13), e2115699119
Brian2CUDA: flexible and efficient simulation of spiking neural network models on GPUs Denis Alevi, Marcel Stimberg, Henning Sprekeler, Klaus Obermayer, Moritz Augustin Frontiers in Neuroinformatics 16: 883700
On Lottery Tickets and Minimal Task Representations in Deep Reinforcement Learning Marc Aurel Vischer, Robert Tjarko Lange, Henning Sprekeler ICLR 2022
Learning not to learn: Nature versus nurture in silico Robert Tjarko Lange, Henning Sprekeler AAAI 2022

2021

Self-organization of a doubly asynchronous irregular network state for spikes and bursts Filip Vercruysse, Richard Naud, Henning Sprekeler PLoS Computational Biology 17(11): e1009478
Hebbian plasticity in parallel synaptic pathways: A circuit mechanism for systems memory consolidation Michiel Remme, Urs Bergmann, Denis Alevi, Susanne Schreiber, Henning Sprekeler, Richard Kempter PLoS Computational Biology 17(12): e1009681
Learning excitatory-inhibitory neuronal assemblies in recurrent networks Owen Mackwood, Laura B Naumann, Henning Sprekeler eLife 2021;10:e5971

2020

A thalamocortical top-down circuit for associative memory M Belén Pardi, Johanna Vogenstahl, Tamas Dalmay, Teresa Spanò, De-Lin Pu, Laura B Naumann, Friedrich Kretschmer, Henning Sprekeler, Johannes J Letzkus Science 370:844-848
Learning prediction error neurons in a canonical interneuron circuit Loreen Hertäg, Henning Sprekeler eLife 2020;9:e57541
Presynaptic inhibition rapidly stabilises recurrent excitation in the face of plasticity Laura Bella Naumann, Henning Sprekeler PLoS Comput Biol 16(8): e1008118

2019

Modeling grid fields instead of modeling grid cells Sophie Rosay, Simon Weber, Marcello Mulas Journal of Computational Neuroscience 47(1):43-60
Amplifying the redistribution of somato-dendritic inhibition by the interplay of three interneuron types Loreen Hertaeg, Henning Sprekeler PLoS Computational Biology 15 (5), e1006999
A local measure of symmetry and orientation for individual spikes of grid cells Simon Nikolaus Weber, Henning Sprekeler PLoS Computational Biology 15 (2), e1006804

2018

Sparse bursts optimize information transmission in a multiplexed neural code R. Naud, H. Sprekeler PNAS, 115(27):E6329-E6338
Learning place cells, grid cells, and invariances with excitatory and inhibitory plasticity S.N. Weber, H. Sprekeler eLife 2018;7:e34560

2017

Memory replay in balanced recurrent networks N. Chenkov, H. Sprekeler, R. Kempter PLoS Computational Biology 13(1): e1005359
Nonlinear Bayesian filtering and learning: a neuronal dynamics for perception A. Kutschireiter, S.C. Surace, H. Sprekeler, J.P. Pfister Scientific Reports 7:8722, DOI:10.1038/s41598-017-06519-y
Functional consequences of inhibitory plasticity: homeostasis, the excitation-inhibition balance and beyond H. Sprekeler Current Opinion in Neurobiology 43, 198-203

2016

Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons K.A. Wilmes, H. Sprekeler, S. Schreiber PLoS Computational Biology, 12(2), e1004768
Receptive field formation by interacting excitatory and inhibitory plasticity Claudia Clopath, Tim P Vogels, Robert C Froemke, Henning Sprekeler BioRxiv

2015

Inheritance of Hippocampal Place Fields Through Hebbian Learning: Effects of Theta Modulation and Phase Precession of Structure Formation T. D'Albis, J. Jaramillo, H. Sprekeler, R. Kempter Neural Computation, 27(8), 1624-1672

2014

An Extension of Slow Feature Analysis for Nonlinear Blind Source Separation H. Sprekeler, T. Zito and L. Wiskott Journal of Machine Learning Research 15, 921-947

2013

Reinforcement Learning using a Continuous Time Actor-Critic Framework with Spiking Neurons N. Fremaux, H. Sprekeler, W. Gerstner PLoS Computational Biology, 9(4): e1003024
Changing the responses of cortical neurons from sub- to supra-threshold using single spikes in vivo V. Pawlak, D. S. Greenberg, H. Sprekeler, W. Gerstner, J. Kerr eLife 2013;2:e00012

2012

The silent period of evidence integration in fast decision making J. Rüter, H. Sprekeler, W. Gerstner, M. H. Herzog PloS One 8(1):e46525
Theory and simulation in neuroscience W. Gerstner, H. Sprekeler, G. Deco Science 338:60-65
Perceptual learning, Roving & the Unsupervised Bias M. H. Herzog, K. C. Aberg, N. Fremaux, W. Gerstner, H. Sprekeler Vision Research, 61:95-99

2011

Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks T. Vogels*, H. Sprekeler*, F. Zenke, C. Clopath and W. Gerstner Science, 334:1569-1573
Paradoxical evidence integration in rapid decision processes J. Rüter, N. Marcille, H. Sprekeler, W. Gerstner and M. Herzog PLoS Computational Biology, 8(2):e1002382
On the Relation of Slow Feature Analysis and Laplacian Eigenmaps H. Sprekeler Neural Computation 23:3287-3302
A Theory of Slow Feature Analysis for Transformation-Based Input Signals with an Application to Complex Cells H. Sprekeler and L. Wiskott Neural Computation 23:303-335

2010

Functional Requirements for Reward-modulated Spike Timing-Dependent Plasticity N. Fremaux*, H. Sprekeler* and W. Gerstner Journal of Neuroscience 30:13326-13337
Slow Feature Analysis L. Wiskott, P. Berkes, M. Franzius, H. Sprekeler and N. Wilbert Scholarpedia, 6(4):5282

2009

Code-Specific Policy-Gradient Rules for Spiking Neurons H. Sprekeler, G. Hennequin and W.Gerstner Advances in Neural Information Processing Systems 22 (NIPS 2009)

2008

Predictive Coding and the Slowness Principle: An Information-Theoretic Approach F. Creutzig and H. Sprekeler Neural Computation 20:1026-41

2007

Slowness and Sparseness lead to Place, Head-Direction and Spatial-View Cells M. Franzius*, H. Sprekeler* and L. Wiskott Neural Computation 20:1026-41
Slowness: An Objective for Spike-Timing-Dependent Plasticity? H. Sprekeler, C. Michaelis and L. Wiskott PLoS Computational Biology 3(6):e112

2004

Positive Correlations in Tunneling through coupled Quantum Dots G. Kießlich, H. Sprekeler, A. Wacker, and E. Schöll Semiconductor Science and Technology 19, S 37
Coulomb Effects in Tunneling through a Quantum Dot Stack H. Sprekeler, G. Kießlich, A. Wacker, and E. Schöll Phys. Rev. B 69, 125328